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middle-aged man

Practice targeted AMC-style multiple-choice questions on middle-aged man.

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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 62-year-old male presents with a three-month history of intermittent rectal bleeding and altered bowel habits. His past medical history is unremarkable. A colonoscopy was performed, and a still image is shown. What is the MOST appropriate next step in management?

A. Recommend a high-fiber diet and monitor symptoms
B. Administer high-dose corticosteroids
C. Prescribe a course of broad-spectrum antibiotics
D. Surgical resection
E. Initiate iron supplementation and repeat colonoscopy in 6 months
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A 67-year-old man with a history of type 2 diabetes mellitus and hypertension presents to the emergency department with sudden onset of right-sided weakness and slurred speech that began 2 hours ago. He has no history of atrial fibrillation or previous strokes. On examination, his blood pressure is 180/95 mmHg, heart rate is 88 bpm, and he is afebrile. Neurological examination reveals right-sided hemiparesis and expressive aphasia. A non-contrast CT scan of the head shows no evidence of hemorrhage. Which of the following is the most appropriate next step in the management of this patient?

A. Perform a CT angiogram of the head and neck
B. Administer intravenous labetalol to lower blood pressure
C. Intravenous thrombolysis with alteplase
D. Refer for urgent carotid endarterectomy
E. Start aspirin therapy
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A 62-year-old male presents to his general practitioner with a six-month history of a painless bulge in his right groin. On examination, a soft swelling is palpable in the right inguinal region, which increases in size on coughing or straining. The swelling is located medial to the inferior epigastric vessels. Which of the following is the most appropriate initial management strategy according to current Australian guidelines?

A. Reassurance and watchful waiting, with advice to return if symptoms worsen.
B. Urgent referral to an emergency department for exclusion of strangulation.
C. Prescription of a truss to provide symptomatic relief.
D. Referral to a physiotherapist for core strengthening exercises.
E. Referral to a general surgeon for consideration of elective repair.
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A 62-year-old man presents with a 4-month history of increasing fatigue, unintentional weight loss of 7 kg, and intermittent upper abdominal discomfort. He reports no change in bowel habits, dysphagia, or vomiting. His past medical history includes hypertension and osteoarthritis. He is a non-smoker and drinks alcohol occasionally. On examination, he is pale. His vital signs are stable. Abdominal examination reveals mild epigastric tenderness but no masses or organomegaly. There is no peripheral lymphadenopathy. Initial blood tests show haemoglobin 92 g/L (reference range 130-170), MCV 74 fL (80-95), ferritin 12 mcg/L (30-300), and CRP 18 mg/L (<5). Liver function tests and renal function tests are within normal limits. Which of the following is the most appropriate initial investigation?

A. Abdominal and pelvic CT scan
B. Faecal occult blood testing
C. Gastroscopy and colonoscopy
D. Upper gastrointestinal barium study
E. Bone marrow biopsy
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A 58-year-old man presents to the emergency department with chest pain radiating to his left arm. His ECG shows ST-segment elevation in leads II, III, and aVF. What is the most appropriate immediate management?

A. Administer thrombolytic therapy
B. Perform an echocardiogram to assess cardiac function
C. Administer sublingual nitroglycerin and observe
D. Start intravenous heparin and admit to the coronary care unit
E. Administer aspirin and initiate primary percutaneous coronary intervention (PCI)
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A 45-year-old man presents to the general practice clinic with a 3-month history of fatigue, weight loss, and night sweats. He has a history of smoking and works as a construction worker. On examination, he has cervical lymphadenopathy and hepatosplenomegaly. Blood tests reveal anemia and elevated lactate dehydrogenase (LDH). A chest X-ray shows a mediastinal mass. What is the most appropriate next step in the management of this patient?

A. Initiate corticosteroid therapy
B. Start empirical antibiotic therapy
C. Order a CT scan of the chest and abdomen
D. Perform a lymph node biopsy
E. Refer for surgical excision of the mass
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A 60-year-old man with a Popeye deformity has no pain but reports mild weakness in supination. What is the most appropriate management?

A. Surgical repair
B. NSAIDs
C. Corticosteroid injection
D. Observation
E. Physical therapy
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 58-year-old male presents to your GP clinic complaining of a dragging sensation in his right groin, particularly when standing for long periods. He denies any pain, nausea, or vomiting. On examination, you note the finding in the image. Palpation reveals a soft, reducible mass. What is the MOST appropriate next step in management?

A. Referral to a general surgeon for elective repair
B. Referral to physiotherapy for core strengthening exercises
C. Urgent referral to the emergency department
D. Prescription of a truss for symptomatic relief
E. Reassurance and watchful waiting
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A 62-year-old male presents to his general practitioner with a six-month history of a painless swelling in his right groin. He reports that the swelling becomes more prominent when he strains or coughs and reduces when he lies down. On examination, a soft, reducible bulge is palpable in the right inguinal region. The bulge is felt to emerge medial to the inferior epigastric vessels. Which of the following is the most appropriate next step in management, according to current Australian guidelines?

A. Referral to a physiotherapist for core strengthening exercises.
B. Referral to a general surgeon for elective open or laparoscopic inguinal hernia repair.
C. Urgent referral to an emergency department for assessment of possible strangulation.
D. Reassurance and watchful waiting, with advice on lifestyle modifications.
E. Prescription of a truss to support the hernia.
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 35-year-old male presents with a painless lesion on his nose that has been present for several months. He denies any trauma or recent illness. Examination reveals the image shown. What is the most appropriate initial management?

A. Topical corticosteroids
B. Topical retinoids
C. Excisional biopsy
D. Oral antibiotics
E. Cryotherapy
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A 45-year-old man presents to the emergency department with sudden onset of severe abdominal pain radiating to the back. He is a smoker and has a history of hypertension. On examination, he is diaphoretic, with a heart rate of 120 bpm and blood pressure of 90/60 mmHg. Abdominal examination reveals a pulsatile mass in the midline. What is the most likely diagnosis?

A. Acute pancreatitis
B. Ruptured abdominal aortic aneurysm
C. Acute mesenteric ischemia
D. Perforated peptic ulcer
E. Renal colic
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 40-year-old man presents with a painless, slowly growing lesion on his nose for the past 8 months. He denies any trauma or previous skin conditions. Examination reveals the pictured lesion. What is the MOST appropriate next step in management?

A. Cryotherapy
B. Observation with serial photography
C. Referral for Mohs micrographic surgery
D. Punch biopsy for histological diagnosis
E. Topical corticosteroid application
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 62-year-old male presents with left lower quadrant pain, fever, and leukocytosis. A CT scan of the abdomen and pelvis is performed, the axial view is shown. What is the most appropriate next step in management?

A. Order a barium enema to assess for fistula
B. Prescribe oral antibiotics and a high-fiber diet
C. Perform a colonoscopy to rule out malignancy
D. Schedule elective sigmoid colectomy
E. Initiate intravenous antibiotics and bowel rest
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A 55-year-old farmer presents with a week of fever, severe headache, and myalgia. He reports recent exposure to lambing ewes on his property. Physical examination is unremarkable except for mild hepatomegaly and normal vital signs. Considering the patient's occupation, exposure history, and clinical presentation, what is the most likely diagnosis?

A. Q fever
B. Brucellosis
C. Leptospirosis
D. Ross River fever
E. Influenza
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents with iron deficiency anemia. The provided CT was performed. What is the MOST likely cause of his anemia?

A. Cameron lesions
B. Vitamin B12 deficiency
C. Gastric malignancy
D. Hookworm infestation
E. Pernicious anemia
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 35-year-old man presents with a painless lesion on his nose, present for 6 months. Examination reveals the image shown. What is the MOST likely diagnosis?

A. Angioma
B. Squamous cell carcinoma
C. Melanoma
D. Basal cell carcinoma
E. Eosinophilic granuloma
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 62-year-old male presents with LLQ pain and fever. The provided image was obtained. What is the most appropriate initial management?

A. Surgical consultation for possible resection
B. Oral antibiotics and outpatient follow-up
C. Colonoscopy to rule out malignancy
D. Stool culture to rule out infectious colitis
E. IV antibiotics and admission for observation
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A 55-year-old farmer presents with a week of severe retro-orbital headache, fever, and myalgia. He reports recent exposure to birthing sheep on his property. On examination, he is febrile (39.5°C) and mildly jaundiced. Liver enzymes are elevated (ALT 250 U/L). Chest X-ray is clear. What is the most likely diagnosis?

A. Leptospirosis
B. Viral hepatitis A
C. Influenza
D. Brucellosis
E. Q fever
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 55-year-old man presents with a slowly growing lesion on his nose that he first noticed about 6 months ago. He reports occasional mild discomfort but no bleeding. He has a history of significant sun exposure due to his occupation. His medical history is otherwise unremarkable. On examination, vital signs are normal. The lesion appears as shown in the image. Regional lymph nodes are not enlarged. Considering the patient's history, risk factors, and the appearance of the lesion, what is the most appropriate initial step in the management of this patient?

A. Apply a high-potency topical corticosteroid cream
B. Excisional or incisional biopsy of the lesion
C. Observe the lesion for a further 3 months and review
D. Order a CT scan of the facial bones and sinuses
E. Refer directly to a plastic surgeon for cosmetic removal
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An incarcerated inguinal hernia as seen on CT
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 59-year-old male presents with a painful right groin bulge that has progressively worsened over the past week. He denies fever, chills, nausea, or vomiting. Vitals are stable. The provided image was obtained. What is the MOST appropriate next step?

A. Prescribe analgesics and discharge with surgical follow-up
B. Order a bowel preparation
C. Attempt manual reduction with sedation
D. Initiate broad-spectrum antibiotics
E. Surgical consultation for operative management
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 58-year-old male presents with iron deficiency anemia and a change in bowel habits. A colonoscopy was performed, and the image is shown. Biopsies were taken. Assuming the biopsies confirm malignancy, what is the next step?

A. Repeat colonoscopy in 6 months
B. Referral to a gastroenterologist for endoscopic mucosal resection
C. Fecal immunochemical test (FIT)
D. Initiate chemotherapy
E. CT scan of the abdomen and pelvis
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A 45-year-old man presents to his GP with a 3-month history of gradually enlarging, painless swelling in the left side of his neck. He denies fever, night sweats, or weight loss. He emigrated from a region with high tuberculosis prevalence five years ago and has no known history of TB exposure or prior testing. On examination, there are multiple firm, non-tender, discrete lymph nodes in the left posterior triangle of the neck, the largest measuring about 3 cm. There are no other palpable nodes or organomegaly. His chest X-ray is clear. What is the most appropriate next diagnostic step?

A. Order a CT scan of the neck to assess the extent of lymphadenopathy
B. Fine needle aspiration cytology and mycobacterial culture of the affected lymph node
C. Perform an Interferon-gamma release assay (IGRA)
D. Initiate empirical treatment with a broad-spectrum antibiotic
E. Excisional biopsy of the largest lymph node for histopathology
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the emergency department with sudden onset severe left flank pain radiating to the groin. He reports some nausea but no vomiting. His temperature is 37.5°C, pulse 88 bpm, BP 130/80 mmHg, respiratory rate 16/min, oxygen saturation 98% on room air. On examination, he has significant left costovertebral angle tenderness. Urinalysis shows microscopic haematuria and trace leukocytes. His creatinine is 90 µmol/L (baseline unknown). An ultrasound of the kidneys is performed, shown in the image. Based on the clinical presentation and the finding shown in the image, what is the most appropriate immediate next step in management?

A. Admit for observation, serial renal function tests, and pain management.
B. Arrange urgent non-contrast CT scan of the kidneys, ureters, and bladder.
C. Arrange urgent flexible cystoscopy and retrograde pyelography.
D. Administer intravenous fluids, opioid analgesia, and prescribe tamsulosin for medical expulsive therapy.
E. Urgent urology consultation for consideration of upper tract decompression.
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 58-year-old male presents to the emergency department complaining of right groin pain that started approximately 6 hours ago. He reports noticing a bulge in his groin for several months, which he could usually push back in. However, today he is unable to reduce it, and the pain has become progressively severe. He denies any fever, nausea, or vomiting. His past medical history includes hypertension and hyperlipidemia, both well-controlled with medications. On examination, his vital signs are stable: blood pressure 130/80 mmHg, heart rate 80 bpm, respiratory rate 16 bpm, and temperature 37.0°C. Abdominal examination is benign. Examination of the groin reveals the finding shown in the image. The area is tender to palpation. Which of the following is the MOST appropriate next step in the management of this patient?

A. Surgical consultation for emergent repair
B. Ultrasound of the groin to rule out testicular torsion
C. Prescription for a truss and referral to a general surgeon for elective repair
D. CT scan of the abdomen and pelvis with intravenous contrast
E. Trial of manual reduction with sedation and analgesia
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male with a history of chronic hepatitis C presents with right upper quadrant pain, weight loss, and jaundice. Physical examination reveals hepatomegaly and mild ascites. Laboratory investigations include elevated alpha-fetoprotein (AFP) levels. Imaging is performed as shown. Considering the clinical context and the findings demonstrated in the imaging, which of the following factors is MOST critical in determining this patient's eligibility for potentially curative surgical resection?

A. Absolute value of serum alpha-fetoprotein
B. Genotype of hepatitis C virus
C. Tumour size and number
D. Patient's chronological age
E. Presence of clinically significant portal hypertension
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old man presents with the condition depicted, which has been present for 12 months and is mildly tender. Initial investigations including hormonal profile, liver function tests, and renal function tests are unremarkable. He takes no regular medications. Considering the clinical presentation and the findings shown, what is the most appropriate next step in the management of this patient?

A. Referral for surgical reduction mammoplasty.
B. Prescription of tamoxifen for symptom relief.
C. Further investigation for rare endocrine causes (e.g., hCG-producing tumour).
D. Urgent referral for breast imaging (ultrasound/mammography).
E. Reassurance and observation with review as needed.
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 55-year-old male presents to the emergency department with a 2-day history of left lower quadrant abdominal pain, associated with a low-grade fever (38.1°C) and mild nausea. He denies vomiting, diarrhoea, or rectal bleeding. On examination, he has localised tenderness in the left iliac fossa. His vital signs are stable: BP 130/80 mmHg, HR 78 bpm, RR 16/min, SpO2 98% on air. Blood tests show a white cell count of 12.5 x 10^9/L and CRP 45 mg/L. An abdominal CT scan is performed (image provided). Considering the clinical presentation and the findings on the provided image, which of the following investigations is most appropriate to recommend for this patient *after* resolution of the acute episode?

A. Colonoscopy in 6-8 weeks
B. Repeat CT scan of the abdomen and pelvis
C. Urgent colonoscopy within 48 hours
D. Faecal occult blood test
E. Barium enema
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 55-year-old man presents to his GP with a persistent lesion on his nose that has been present for several months and has not changed significantly in size or appearance. He reports it is occasionally itchy but otherwise asymptomatic. His medical history is unremarkable, and vital signs are within normal limits. On examination, you observe the lesion shown in the image. Considering the appearance of this lesion, what is the most appropriate initial step in the management of this patient?

A. Perform a punch or shave biopsy of the lesion.
B. Advise watchful waiting and review in 6 months if it changes.
C. Prescribe a 7-day course of oral flucloxacillin.
D. Initiate treatment with topical hydrocortisone 1%.
E. Refer for Mohs micrographic surgery.
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old male presents with concerns about breast enlargement over the past year. He denies pain or nipple discharge. He takes no medications and reports no significant past medical history. Examination reveals the findings in the image. What is the MOST appropriate initial investigation?

A. Liver function tests
B. Prolactin level
C. Mammography
D. Serum testosterone and estradiol levels
E. Fine needle aspiration
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A 45-year-old farmer presents with a 10-day history of fever, severe retro-orbital headache, and myalgia. He denies cough or dyspnoea. Physical examination is unremarkable. What is the most appropriate initial investigation?

A. Liver function tests
B. Serology for Coxiella burnetii
C. Chest X-ray
D. Blood culture
E. PCR for Coxiella burnetii
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 62-year-old male presents with left lower quadrant pain, fever, and leukocytosis. A CT scan of the abdomen and pelvis is performed (image attached). Assuming the diagnosis, which of the following is the MOST appropriate initial management?

A. Colonoscopy to rule out malignancy
B. Oral antibiotics and outpatient follow-up
C. IV antibiotics, bowel rest, and surgical consultation
D. Stool culture and empiric antibiotics
E. High-fiber diet and increased fluid intake
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 58-year-old male presents with acute onset LLQ pain, low-grade fever, and mild nausea. His vitals are stable. An abdominal CT scan was performed, the axial view is shown. What is the MOST appropriate initial management strategy?

A. Colonoscopy to rule out malignancy
B. IV antibiotics and hospital admission
C. Stool culture and symptomatic treatment
D. Surgical consultation for possible resection
E. Oral antibiotics and outpatient management
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 32-year-old male with Crohn's disease presents with worsening abdominal pain and diarrhea despite being on maintenance infliximab. He denies fever or blood in his stool. An abdominal CT and MRI are performed. Based on the imaging, what is the MOST appropriate next step in management?

A. Initiate treatment with ustekinumab
B. Perform a colonoscopy with biopsy
C. Prescribe a course of oral metronidazole
D. Start a course of oral budesonide
E. Increase the dose of infliximab
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 45-year-old man presents with the finding shown. He denies pain but is concerned about its appearance. What is the MOST appropriate initial step?

A. Surgical referral for elective repair
B. Referral for physiotherapy
C. Reassurance and observation
D. Prescription for a scrotal support
E. CT scan of the abdomen and pelvis
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 55-year-old man presents to his GP with a lesion on his nose that has been slowly enlarging over the past 4 months. He reports no associated pain, itching, or bleeding. He is otherwise well, with no significant past medical history. On examination, vital signs are within normal limits. The lesion is as shown in the image. Considering the clinical presentation and the appearance of the lesion, what is the most appropriate initial step in the management of this patient?

A. Refer the patient directly for Mohs micrographic surgery.
B. Arrange for cryotherapy to the lesion.
C. Prescribe a course of oral antibiotics.
D. Excisional or incisional biopsy of the lesion.
E. Prescribe a high-potency topical corticosteroid cream.
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 48-year-old man with multiple cutaneous hemangiomas presents with crampy abdominal pain and guaiac-positive stools. The provided image was obtained. What is the MOST appropriate initial diagnostic test to identify the source of bleeding?

A. Tagged red blood cell scan
B. Upper endoscopy
C. Barium swallow
D. Colonoscopy
E. Capsule endoscopy
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 58-year-old male presents with fatigue and iron deficiency anemia. Colonoscopy reveals the image shown. Biopsies are taken. Assuming pathology confirms malignancy, what is the MOST appropriate next investigation to determine disease stage?

A. CT scan of the abdomen and pelvis
B. PET-CT scan
C. Endoscopic ultrasound
D. MRI of the abdomen and pelvis
E. Carcinoembryonic antigen (CEA) level
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 55-year-old man presents to the emergency department with sudden onset, severe left flank pain radiating to his groin, associated with nausea. He is afebrile, blood pressure 130/80 mmHg, heart rate 85 bpm. Urinalysis shows 20-30 red blood cells per high-power field. Serum creatinine is within normal limits. An ultrasound is performed. Considering the clinical context and the findings demonstrated in the provided image, which of the following is the most appropriate immediate management step?

A. Initiate empirical broad-spectrum intravenous antibiotics.
B. Prescribe oral tamsulosin and diclofenac and discharge home.
C. Urgent urology consultation for potential decompression.
D. Administer intravenous fluids and opioid analgesia and observe for spontaneous stone passage.
E. Arrange a non-contrast CT KUB as the definitive imaging modality.
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A 62-year-old man presents to the emergency department with a history of palpitations and dizziness that started suddenly 2 hours ago. He has a history of hypertension and is on lisinopril. He denies chest pain, shortness of breath, or syncope. On examination, his blood pressure is 110/70 mmHg, heart rate is 150 bpm (irregular), respiratory rate is 18 breaths per minute, and temperature is 36.7°C. An ECG is performed, showing an irregularly irregular rhythm with no distinct P waves and a narrow QRS complex. Which of the following is the most appropriate initial management step?

A. Initiation of anticoagulation therapy
B. Rate control with a beta-blocker
C. Immediate electrical cardioversion
D. Administration of adenosine
E. Rate control with digoxin
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the ED with left flank pain radiating to his groin. He reports nausea but no vomiting. Vitals are stable. A focused assessment with sonography for trauma (FAST) exam is performed, with a view obtained as shown. What is the MOST appropriate next step in management?

A. Perform a cystoscopy
B. Discharge with analgesics and follow-up with urology
C. Non-contrast CT of the abdomen and pelvis
D. Order serum lipase and amylase
E. Administer intravenous antibiotics
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A 55-year-old man with type 2 diabetes mellitus presents for a routine follow-up. His HbA1c is 9.0% despite being on metformin 1000 mg twice daily. He has a BMI of 32 kg/m² and no history of cardiovascular disease. What is the most appropriate next step in his management?

A. Add a DPP-4 inhibitor
B. Increase the dose of metformin
C. Add a GLP-1 receptor agonist
D. Start basal insulin therapy
E. Add a sulfonylurea
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 45-year-old man presents to his GP with a lesion on his nose that he first noticed about 6 months ago. It has slowly increased in size but is not painful or itchy. He has no significant past medical history and takes no regular medications. On examination, vital signs are stable. The image shows the appearance of the lesion. Considering the clinical presentation and the appearance of the lesion shown, what is the most appropriate initial management step?

A. Reassure the patient and review in 3 months.
B. Excisional biopsy for histological assessment.
C. Prescribe a course of topical corticosteroid cream.
D. Refer immediately for Mohs micrographic surgery.
E. Arrange for cryotherapy in the clinic.
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the emergency department with sudden onset severe left flank pain radiating to the groin. He reports some nausea but no vomiting. His temperature is 37.5°C, pulse 88 bpm, BP 130/80 mmHg, respiratory rate 16/min, oxygen saturation 98% on room air. On examination, he has significant left costovertebral angle tenderness. Urinalysis shows microscopic haematuria and trace leukocytes. His creatinine is 90 µmol/L (baseline unknown). An ultrasound of the kidneys is performed, shown in the image. Considering the patient's presentation and the findings demonstrated in the provided image, the most likely primary mechanism responsible for the severe pain experienced by this patient is:

A. Ischaemic injury to the renal tubules resulting from compromised blood flow.
B. Increased hydrostatic pressure leading to distension of the renal pelvis and collecting system.
C. Reflex spasm of the psoas muscle due to ureteral irritation.
D. Direct irritation of sensory nerve endings in the ureteral wall by the obstructing object.
E. Inflammatory response within the renal parenchyma secondary to bacterial invasion.
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A 55-year-old man presents to the emergency department with sudden onset severe abdominal pain radiating to the back. He has a history of hypertension and is a smoker. On examination, he is diaphoretic and in distress, with a blood pressure of 90/60 mmHg and a heart rate of 110 bpm. Abdominal examination reveals a pulsatile mass in the midline. What is the most likely diagnosis?

A. Acute myocardial infarction
B. Acute pancreatitis
C. Perforated peptic ulcer
D. Renal colic
E. Ruptured abdominal aortic aneurysm
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 68-year-old male presents with fatigue, weight loss, and vague abdominal discomfort. His past medical history includes a recent diagnosis of gastric mixed adenoneuroendocrine carcinoma (MANEC). A CT scan of the abdomen is performed, the results of which are shown. What is the MOST appropriate next step in management?

A. Surgical resection of liver lesions
B. Referral for liver transplant evaluation
C. Observation with serial imaging
D. Palliative chemotherapy
E. Initiation of immunotherapy
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A 55-year-old male presents with chest pain that radiates to his left arm and jaw, accompanied by diaphoresis and nausea. ECG shows ST-segment elevation in leads II, III, and aVF. What is the most likely diagnosis?

A. Unstable angina
B. Acute inferior myocardial infarction
C. Acute anterior myocardial infarction
D. Pulmonary embolism
E. Aortic dissection
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A 55-year-old man with a history of hypertension presents for a routine check-up. His blood pressure is consistently measured at 160/95 mmHg despite lifestyle modifications. He is currently on perindopril 5 mg daily. According to Australian guidelines, what is the most appropriate next step in managing his hypertension?

A. Switch to losartan
B. Refer for renal artery imaging
C. Add hydrochlorothiazide
D. Add amlodipine
E. Increase perindopril to 10 mg daily
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A 58-year-old man with a 10-year history of Type 2 diabetes presents to the clinic for a routine follow-up. He is currently on metformin and lifestyle modifications, but his HbA1c has increased to 8.5% over the past six months. He reports adherence to his medication and diet but has a sedentary lifestyle. What is the most appropriate next step in managing his diabetes?

A. Refer for bariatric surgery
B. Add a GLP-1 receptor agonist
C. Add a sulfonylurea
D. Increase the dose of metformin
E. Start basal insulin therapy
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents to his GP with a 6-month history of intermittent postprandial fullness and mild dysphagia, particularly with solid foods. He reports occasional regurgitation but denies significant heartburn or chest pain. His vital signs are stable, and physical examination is unremarkable. Recent blood tests show mild iron deficiency anaemia. The provided image is from a CT scan of the chest and upper abdomen performed as part of his investigation. Considering the clinical presentation and the significant anatomical finding demonstrated in the image, what is the most appropriate next step in the management of this patient?

A. Urgent upper gastrointestinal endoscopy to assess for malignancy.
B. Initiation of high-dose proton pump inhibitor therapy.
C. Prescription of iron supplements and dietary advice.
D. Barium swallow study to further characterise the anatomy.
E. Referral for surgical assessment and consideration of operative repair.
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old male presents to his GP complaining of bilateral breast enlargement over the past year. He denies any pain or tenderness. He takes no medications and reports no significant past medical history. Examination reveals the findings in the image. What is the MOST appropriate initial investigation?

A. Prolactin level
B. Liver function tests
C. Fine needle aspiration
D. Serum testosterone and estradiol levels
E. Mammography
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